A Drug against COVID-19 Complications is Registered in Russia
On June 5th, the Ministry of Health of the Russian Federation registered the original drug Levilimab (trade name Ilsira), intended for the inhibition of harsh complications of coronavirus infection – a cytokine storm. Levilimab is developed and produced by Russian biotechnology company BIOCAD.
Levilimab received state approval through a fast-track mechanism, according to Decree No. 441 of the Government of the Russian Federation of April 4, 2020, since its mechanism of action is associated with the control of the cytokine storm, which is one of the manifestations of coronavirus infection.
"The results of a clinical trials of the drug, initiated on April 24, demonstrate that levilimab therapy can significantly reduce mortality among patients with COVID-19 and the burden on the health system," comments Dmitry Morozov, General Director of BIOCAD.
The drug can be prescribed to patients with a severe course of the disease, when the patient’s immune system overreacts to the virus (the so-called cytokine storm develops) and excessive inflammation can lead to a fatal outcome. Levilimab is administered hypodermically and treatment by the drug is possible only in hospitals.
According to the latest temporary guidelines for the prevention, diagnosis and treatment of COVID-19 of the Russian Health Ministry, Interleukin 6 (IL-6) blockers, monoclonal antibodies to the IL-6 receptor, are used to inhibit cytokine storm among COVID-19 patients. Levilimab is a Russian-made original inhibitor of Interleukin 6 receptor which was originally being developed for treatment of rheumatoid arthritis.